Relationship Between Zombie Cells And Obesity Is Complex
The researchers are now studying the brains of the obese mice in the hope that it will help understand the human brain patterns or a specific target in case of a type of anxiety. The scientists have been able to correlate obesity and distantly linked obesity to a number of different neuropsychiatric disorders like anxiety and depression. However, the precise character of this connection still remains unclear, which in turn makes treatment difficult.
In the current research, the new abundant target cells have been named “zombie cells.” The mouse models used by the University of Newcastle have shown that the overweight mice have more of zombie cells in a specific region of the brain which generally controls anxiety. These conclusions could be confirmed as the removal of these malfunctioning cells showed less of anxious behavior in the mice. The target cells, zombie cells, also known as senescent cells, have the tendency to build up in the specific parts of the brain. These semi-dormant cells tend to impair the normal chore defined in that region.
These identified cells have a role to play in the symptoms of aging such as muscle weakness, osteoporosis, and diabetes. It has been potentially proved that the cells are the key donors to obesity-induced anxiety. The study shows that obese mice have more fat cells accumulated in the brain’s lateral ventricle, which is the region that controls stress reaction. The senescent cells in these regions increased in the obese mice. The facts linked to the senescence cells and fat build-up is still vague; however, the researchers have been able to produce a drug that can kill these cells and reduce fat accumulation in order to resume normal growth of the cells. The current research can help open a new door for the therapeutic methods for curing obesity-induced neuropsychiatric dysfunction.
This theory is to date exploratory as a lot more study has to be done. The elimination of the zombie cells from the specific brain region is not easy even though the exact drug target for the anxiety treatment has been discovered. The traumatic incidences can become imprinted in our memory which is why the Mainz University Medical Center researchers have recently shed new light on focusing the positive experiences of a person’s memory using plain and simple drug treatments. The positive memory formation processes study can help treat the anxiety-related problems and post-traumatic stress disorder (PTSD) as well as develop potential preventive measures.